Kimera and Vitti Labs Placental MSC Exosomes.
State-of-the-Art Regenerative Medicine.


Welcome to the future of regenerative and anti-aging medicine!  There are many kinds of exosomes. Here we are specifically talking about two products: Xoglo™ by Kimera and EV-Pure™ by Genisent.  These are both exosome products derived from placental mesenchymal stem cells (MSCS), which are cells with very special properties.  We’ll call these specific exosome products MEVS for short. 


MEVS are tiny spheres, surrounded by membranes, filled with potent growth factors, proteins and micro-rna.  MEVS travel intact through the bloodstream, and proteins on their surfaces help them reach their target cells.  Exosomes from placental MSCS target virtually every organ and tissue in the body. Some, for example, contain brain-derived neurotrophic growth factor, and these are designed for neurons in the brain.  The spheres are taken up by stem cells and other cells throughout your body, where they encourage a variety of benefits. They influence your own dormant stem cells to come out of hibernation, proliferate and heal.  They have potent anti-inflammatory effects, changing macrophages and t-cells from inflammatory states to non-inflammatory states. Some MEVS preferentially go to injured or otherwise dysregulated tissues and promote healing and homeostasis.  They may even suppress tumor genes. 


MEVS have been shown to promote healing of damaged tissues and creation of new blood vessels while reducing scar formation.  They have profound and far-reaching effects which can often be felt immediately with continued improvement noted for months after a treatment.  After a series of 3 initial treatments, spaced about 3 months apart, benefits can be maintained with once to twice per year maintenance.

The Benefits of EXOSOMES

Some of the benefits our patients have reported from IV exosomes include:

  • Increased stamina

  • Faster recovery after workouts

  • Decreased pain and swelling in both large and small joints

  • Resolution of clicking/cracking/popping in joints

  • “Increased joint lubrication”

  • Improved vision and mental clarity

  • Better sleep

  • Enhanced sense of well-being

  • Reduced cravings

  • Increased satiety

  • Craving vegetables

  • Improvement of long-standing skin and lung conditions

  • Improved focus and concentration

  • Decreased brain fog

  • Face and body looking and feeling younger, and much more!

Clinically, Kimera MEVS have been shown to increase testosterone, decrease inflammation, improve sperm count and reverse motor deficits from long-standing spinal cord injuries (see Doug Spiel MD on Youtube).  

Donated placental tissue is collected during planned full-term cesarean births in the USA.  Donor mothers are pre-selected based on an intensive social history then screened just like organ donors.  After collection, the tissues go through a series of tests to ensure purity and safety.  The MSCS are then carefully isolated, cultured in non-biological broths and stimulated to secrete exosomes.  The exosomes are then filtered, concentrated and suspended in preservative-free saline. 

Why choose MEVS vs. Amniotic fluid exosomes or exosomes from adult bone marrow or fat MSCS? 

Virtually every cell can produce exosomes.  The quality of exosomes depends on the cells that produce them.  Consider what different stem cells are designed to do. Placental MSCS are pericytes (they cling to blood vessels) where they secrete MEVS directly into the bloodstream.  These exosome signals support the growth and development of every organ and tissue of a developing fetus, reduce inflammation (to protect the fetus from being attacked by the mother’s immune system) and reduce the risk of tumor development.  They are young and they are potent. Thousands of studies have demonstrated the safety and widespread benefits of birth tissue MSCS on tissue regeneration, auto-immune, neurological conditions and much more. In contrast, amniotic fluid contains a very small proportion of MSCS and a large portion of epithelial cells and fibroblasts plus other contaminants.  Adult bone marrow and fat-derived MSCS have different functions. Bone marrow MSCS are great for healing fractures. Fat MSCS have actually been shown to increase inflammation and insulin resistance. Furthermore, adult-derived MSCS have been diminished with age and potentially damaged by prolonged exposure to drugs, toxins, infections, inflammation, stress and the like. 





Most of the studies showing MSC benefits used cells that had never been frozen.  Unfortunately, the freezing and thawing process plus FDA-compliance practices ensure that most allographic (from someone else’s) stem cells in the USA do not survive the thaw.  Cost: small doses of stem cells, containing 2 million MSCS or less, cost several thousand dollars.  Giving concentrated MEVS allows for much more potent doses (see next section) at more affordable prices, making repeated dosing accessible.  Buying the cow vs…: we now know that MSC also stands for “master signaling cell.”  MSCS don’t exert their regenerative and other benefits by engrafting and becoming a part of the host.  They do so through the paracrine effect, secreting MEVS that awaken and stimulate the recipient’s own stem cells to grow into healthy new blood vessels, nerves and other tissues.  They send signals for a short time and then disappear from your body.   Bioavailability: MEVS are a fraction of the size of stem cells, and do not contain organelles, DNA, mitochondria, etc.  Compared to stem cells, they are safer, are not rejected by the immune system, travel throughout the body and reach target tissues, including the brain, more quickly and easily.

How can we compare the potency and efficacy of our exosomes with MSCS?


One 5ml vial of Xoglo™ contains 5 billion exosomes, and is estimated to have the regenerative capacity of 160 million live MSCS over 24 hours (based on in vitro research).  A 1ml full-strength vial of EV-Pure™ has 15 billion exosomes.  Remember, a really potent MSC stem cell product has only 2 million MSCS per ml, most of which are dead at the time of injection. 


Douglas Spiel, MD, has presented a number of cases where he has helped quadriplegic patients with long-standing spinal cord injuries regain muscle control, strength and more using Kimera exosomes.  Dr. Haas has treated people using both stem cells and exosomes, having administered over 85 doses of MEVS as of 12/17/19. Based on her knowledge and experience, the increased potency, efficacy, and safety of exosomes vs stem cells seems overwhelmingly clear.  EV-Pure™ is newer to the market, and incorporates remarkable innovation in the field of MSC exosomes. Between 11/6/19 and 12/17/19, dr. Haas has given EV-Pure™ to 12 patients via iv, nasal and intrauterine routes, 9 of whom had previously received Xoglo™.  So far EV-Pure™ has been very well-tolerated with effects comparable to Xoglo™ in the short term, for patients with a wide variety of therapeutic goals.  We offer EV-Pure™ as a more cost-effective way to achieve higher doses.   ​


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